Note on Digitalis Saponins

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Studies on Digitalis

T IS undisputed that the administration of digitalis to patients with many forms of congestive heart failure results in an improvement in both the clinical state and in the abnormal circulatory dynamics that are characteristic of heart failure.'-6 The effects of digitalis in subjects without heart failure are less well defined. Although some glycosides augment the contractile force of nonfailin...

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Studies on Digitalis VI

T IS undisputed that the administration of digitalis to patients with many forms of congestive heart failure results in an improvement in both the clinical state and in the abnormal circulatory dynamics that are characteristic of heart failure.'-6 The effects of digitalis in subjects without heart failure are less well defined. Although some glycosides augment the contractile force of nonfailin...

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The demonstration that the long-continued administration of certain sex hormones results in the production of malignant changes in mice, 2, 4, 6 suggested that other compounds of cydopentenophenanthrene structure should be studied for similar effects. The cardiac glucosides and saponins were chosen because they present certain variations in molecular structure not found in the sex hormones, bil...

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Digitalis.

Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in his late 18th century monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea). Despite their widespread acceptance into medical practice in the ensuing 200 years, both the efficacy and the safety of this class of drugs continu...

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ژورنال

عنوان ژورنال: The Journal of the American Pharmaceutical Association (1912)

سال: 1921

ISSN: 0898-140X

DOI: 10.1002/jps.3080100409